Q&A with Dr. Hala Saad: COVID-19 Bivalent Boosters

Two new­ly updat­ed COVID-19 boost­er shots are now avail­able in the U.S. The new biva­lent boost­ers are expect­ed to pro­vide increased pro­tec­tion against the omi­cron vari­ant. We spoke with Dr. Hala Saad, Infec­tious Dis­ease physi­cian at Quin­cy Med­ical Group, to help break down the impor­tant details about this new boost­er and who is eligible.

What makes this boost­er dif­fer­ent from pre­vi­ous boost­ers?
Pre­vi­ous boost­ers tar­get the orig­i­nal SARS-CoV2 strain. The new boost­ers cov­er the new vari­ants, they are named biva­lent” because they cov­er both the orig­i­nal strain and the new Omi­cron BA.4/BA.5 variants.

Who should get the boost­er?
Who should get the biva­lent boost­er: peo­ple ages 12 and old­er should receive one biva­lent mRNA boost­er after com­ple­tion of a mono­va­lent pri­ma­ry series; it replaces all pri­or boost­er rec­om­men­da­tions of this age group.

  • Rec­om­men­da­tions for use of a biva­lent Mod­er­na boost­er dose in peo­ple ages 18 years and older
  • Rec­om­men­da­tions for use of a biva­lent Pfiz­er-BioN­Tech boost­er dose in peo­ple ages 12 years and older

When should you get the boost­er?
You should get the boost­er once you have com­plet­ed your pri­ma­ry vac­ci­na­tion series with the mono­va­lent vac­cine, or a boost­er dose with mono­va­lent vac­cine with a lag peri­od of two months.

How effec­tive are the boost­ers?
Sci­ence and med­ical com­mu­ni­ties believe the biva­lent boost­ers will work bet­ter in pre­vent­ing Omi­cron BA.4/5 infec­tions while keep­ing the strong pro­tec­tion against severe dis­ease from all COVID-19 strains.

To eval­u­ate the over­all effec­tive­ness of biva­lent boost­er vac­cines, a clin­i­cal study used a biva­lent COVID-19 vac­cine that tar­get­ed both the orig­i­nal strain of COVID-19 as well as a dif­fer­ent Omi­cron sub­vari­ant called BA.1. The data from that study were eval­u­at­ed by the FDA and led to the Emer­gency Use Autho­riza­tion for the new biva­lent booster.

In the study, researchers found that peo­ple who received the BA.1 biva­lent boost­er had a bet­ter immune response against COVID-19 Omi­cron sub­vari­ant BA.1 com­pared with those who received the orig­i­nal (mono­va­lent) boost­er. The Mod­er­na part of the study eval­u­at­ed 600 adults age 18 years and old­er, while the Pfiz­er-BioN­Tech part of the study looked at 600 peo­ple age 55 and old­er. Find­ings from the two stud­ies were sim­i­lar. (Ref­er­ence: mskcc​.org)

What if I still have more ques­tions?
If you have addi­tion­al ques­tions about the boost­er, we rec­om­mend speak­ing to your pri­ma­ry care provider. If you need a pri­ma­ry care provider, we can help you with that. Vis­it quin​cymed​group​.com or call our Pri­ma­ry Care Access Line at (217) 222‑6550, ext. 3325.

Health Topics: