ClariFix® Cryotherapy for Chronic Rhinitis

What is chronic rhinitis?

Chronic rhinitis is frequent inflammation of the nose with symptoms such as a runny nose, nasal congestion, and post-nasal drip (mucus in the throat). The exact causes of chronic rhinitis are unknown, but out-of-balance nasal nerves play a contributing factor. The nerves in your nose transmit signals to your brain regulating all sorts of functions. When these nerves become hyperactive or out of balance, they send more signals than are necessary for the nose to perform its normal jobs, such as protecting the body from infectious agents. This can cause your nose to respond like it’s fighting an illness. The nasal linings will become inflamed (congestion) and mucus production will increase (runny nose), causing these annoying symptoms – even when you aren’t sick.

There are limited treatment options for the more than 24 million patients suffering from chronic rhinitis in the US alone.^1,2 Many are unsatisfied with medical therapy, and 2.5 million are resistant to medical therapy^1,2 altogether.

Medical treatments for chronic rhinitis, like nasal sprays, drops, pills, and allergy shots, help manage frequent runny nose, congestion, and post-nasal drip symptoms; however:

• They may require daily use
• Symptoms can persist despite these treatments
• Side effects may occur from prolonged usage, including nasal and throat dryness, nosebleeds, and headaches^3,4

Finally, a Fix to Stop the Drip and Sniff

Get to the root of your runny nose and nasal congestion with ClariFix®, an in-office cooling treatment that stops the source of your chronic rhinitis symptoms. The ClariFix® device uses a minimally-invasive treatment called “cryotherapy” to interrupt the signals from the out-of-balance nerves. When the cold temperature hits the out-of-balance nerves, the nerve signals are temporarily interrupted. The nerves are no longer telling the nose to drip, run, and swell.

Cool Treatment with ClariFix® Cryotherapy

• Cryotherapy is safe and performed right in the doctor’s office
• Minimal recovery time and post-treatment care
• 4 out of 5 patients reporting long-lasting symptom improvement.^7,8
• Most patients begin to see improvement between 2 and 6 weeks after treatment.

Is ClariFix® Cryotherapy Right for You?

There are a few key symptoms for chronic rhinitis. It’s important for both you and your physician to understand the severity of these symptoms. Take the ClariFix® Symptom Assessment and schedule an appointment with one of our ENT specialists with Quincy Medical Group’s Ear, Nose, and Throat (ENT) department to determine if ClariFix® is right for you.

The ClariFix device is intended to be used as a cryosurgical tool for the destruction of unwanted tissue during surgical procedures, including in adults with Chronic Rhinitis.© Arrinex, Inc. All rights reserved. ClariFix is a registered trademark of Arrinex, Inc. MRK-0833 Rev A.

1. CDC: https://www.cdc.gov/nchs/fastats/allergies.htm.

2. Settipane, Russell A. “Epidemiology of vasomotor rhinitis.” The World Allergy Organization Journal 2.6 (2009): 115.

3. https://www.flonase.com/allergies/nasal-steroid-side-effects/. Accessed November 15, 2017.

4. Nasal Corticosteroid Sprays, U.S. National Library of Medicine. http://www.nlm.nih.gov/medlineplus/ency/patientinstructions/000404.htm. Accessed November 15, 2017.

5. Prescribing information for: Sudafed 63D0DF®, Sinex™ Severe Nasal Spray, Atrovent® HFA, Flonase®

6. Adverse events were those usually associated with post-cryosurgery in the nasal passageway and included: pain/discomfort, headache, facial pain, bleeding, dry nose, ear blockage. By day 90, symptoms had either resolved or were rated as mild.

7. K162608, Data on File: A2014-02 Clinical Report, Arrinex.

8. Hwang P, et al. “Cryosurgical Posterior Nasal Tissue Ablation for the Treatment of Rhinitis.” Int Forum Allergy Rhinol. 2017 Oct;7(10):952-956.