An ectopic pregnancy is an abnormal pregnancy that occurs outside the womb (uterus). The baby (fetus) cannot survive, and often does not develop at all in this type of pregnancy.
Tubal pregnancy; Cervical pregnancy; Abdominal pregnancy
An ectopic pregnancy occurs when a pregnancy starts outside the womb (uterus). The most common site for an ectopic pregnancy is within one of the tubes through which the egg passes from the ovary to the uterus (fallopian tube). However, in rare cases, ectopic pregnancies can occur in the ovary, stomach area, or cervix.
An ectopic pregnancy is often caused by a condition that blocks or slows the movement of a fertilized egg through the fallopian tube to the uterus. This may be caused by a physical blockage in the tube by hormonal factors and by other factors, such as smoking.
Most cases of scarring are caused by:
Up to 50% of women who have ectopic pregnancies have had swelling (inflammation) of the fallopian tubes (salpingitis) or pelvic inflammatory disease (PID).
Some ectopic pregnancies can be due to:
The following may also increase the risk of ectopic pregnancy:
In a few cases, the cause is unknown.
Sometimes, a woman will become pregnant after having her tubes tied (tubal sterilization). Ectopic pregnancies are more likely to occur 2 or more years after the procedure, rather than right after it. In the first year after sterilization, only about 6% of pregnancies will be ectopic, but most pregnancies that occur 2 - 3 years after tubal sterilization will be ectopic.
Ectopic pregnancy is also more likely in women who have:
Ectopic pregnancies occur in 1 in every 40 to 1 in every 100 pregnancies.
If the area of the abnormal pregnancy ruptures and bleeds, symptoms may get worse. They may include:
Internal bleeding due to a rupture may lead to low blood pressure and fainting in around 1 out of 10 women.
The health care provider will do a pelvic exam, which may show tenderness in the pelvic area.
Tests that may be done include:
A rise in quantitative HCG levels may help tell a normal (intrauterine) pregnancy from an ectopic pregnancy. Women with high levels should have a vaginal ultrasound to identify a normal pregnancy.
Other tests may be used to confirm the diagnosis, such as:
Ectopic pregnancies cannot continue to birth (term). The developing cells must be removed to save the mother's life.
You will need emergency medical help if the area of the ectopic pregnancy breaks open (ruptures). Rupture can lead to shock, an emergency condition. Treatment for shock may include:
If there is a rupture, surgery (laparotomy) is done to stop blood loss. This surgery is also done to:
In some cases, the doctor may have to remove the fallopian tube.
A minilaparotomy and laparoscopy are the most common surgical treatments for an ectopic pregnancy that has not ruptured. If the doctor does not think a rupture will occur, you may be given a medicine called methotrexate and monitored. You may have blood tests and liver function tests.
One-third of women who have had one ectopic pregnancy are later able to have a baby. A repeated ectopic pregnancy may occur in one-third of women. Some women do not become pregnant again.
The likelihood of a successful pregnancy depends on:
The rate of death due to an ectopic pregnancy in the United States has dropped in the last 30 years to less than 0.1%.
The most common complication is rupture with internal bleeding that leads to shock. Death from rupture is rare.
If you have symptoms of ectopic pregnancy (especially lower abdominal pain or abnormal vaginal bleeding), call your health care provider. You can have an ectopic pregnancy if you are able to get pregnant (fertile) and are sexually active, even if you use birth control.
Most forms of ectopic pregnancy that occur outside the fallopian tubes are probably not preventable. However, a tubal pregnancy (the most common type of ectopic pregnancy) may be prevented in some cases by avoiding conditions that might scar the fallopian tubes.
The following may reduce your risk:
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Lobo RA. Ectopic pregnancy: Etiology, pathology, diagnosis, management, fertility prognosis. In: Katz VL, Lentz GM, Lobo RA, Gershenson DM, eds. Comprehensive Gynecology. 5th ed. Philadelphia, Pa: Mosby Elsevier;2007:chap 17.
Barnhart KT. Ectopic pregnancy. N Engl J Med. 2009;361:379-387.